Reward and Behavioral Factors Contributing to the Tonic Activity of Monkey Pedunculopontine Tegmental Nucleus Neurons during Saccade Tasks

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Reward and Behavioral Factors Contributing to the Tonic Activity of Monkey Pedunculopontine Tegmental Nucleus Neurons during Saccade Tasks

The pedunculopontine tegmental nucleus (PPTg) in the brainstem plays a role in controlling reinforcement learning and executing conditioned behavior. We previously examined the activity of PPTg neurons in monkeys during a reward-conditioned, visually guided saccade task, and reported that a population of these neurons exhibited tonic responses throughout the task period. These tonic responses m...

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Contribution of pedunculopontine tegmental nucleus neurons to performance of visually guided saccade tasks in monkeys.

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Reward prediction-related increases and decreases in tonic neuronal activity of the pedunculopontine tegmental nucleus

The neuromodulators serotonin, acetylcholine, and dopamine have been proposed to play important roles in the execution of movement, control of several forms of attentional behavior, and reinforcement learning. While the response pattern of midbrain dopaminergic neurons and its specific role in reinforcement learning have been revealed, the roles of the other neuromodulators remain elusive. Repo...

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Reward prediction error computation in the pedunculopontine tegmental nucleus neurons.

In this article, we address the role of neuronal activity in the pathways of the brainstem-midbrain circuit in reward and the basis for believing that this circuit provides advantages over previous reinforcement learning theory. Several lines of evidence support the reward-based learning theory proposing that midbrain dopamine (DA) neurons send a teaching signal (the reward prediction error sig...

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ژورنال

عنوان ژورنال: Frontiers in Systems Neuroscience

سال: 2016

ISSN: 1662-5137

DOI: 10.3389/fnsys.2016.00094